Diazoxide

Name: Diazoxide
Brand: Tocris Bioscience
SKU: 0964

Tocris Bioscience a Bio-Techne Brand

Catalog # 0964

Citations (4)

COA / SDS

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Key Product Details

Description:	Inhibits AMPA desensitization
Chemical Name:	7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Purity:	≥98% (HPLC)
Molecular Weight:	230.67

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Biological Activity for Diazoxide

Diazoxide is an antihypertensive, activates ATP-dependent K⁺ channels (K_ir6). Induces activation of PKCε, an intermediate in the opening of mitoK_ATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Compound Libraries for Diazoxide

Diazoxide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Diazoxide

M. Wt	230.67
Formula	C₈H₇ClN₂O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	364-98-7
PubChem ID	3019
InChi Key	GDLBFKVLRPITMI-UHFFFAOYSA-N
Smiles	CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Diazoxide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.07	100

Preparing Stock Solutions for Diazoxide

The following data is based on the product molecular weight 230.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.34 mL	21.68 mL	43.35 mL
5 mM	0.87 mL	4.34 mL	8.67 mL
10 mM	0.43 mL	2.17 mL	4.34 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

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References for Diazoxide

References are publications that support the biological activity of the product.

Kim Dox acts more as a PKC-ε activator, and indirectly activates the mitochondiral K_ATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 2006 PMID: 17043673
Yamada and Rothman Dox blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 1992 PMID: 1302270
Trube Opposite effects of tolbut. and Dox on the ATP-dependent K⁺ channel in mouse pancreatic β-cells. Pflugers Arch. 1986 PMID: 2431383

Citations for Diazoxide (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Diazoxide include:

Cox et al. (2014) Chronic neonatal Dox therapy is not associated with adverse effects J Neurosci. 14:49
PMID: 25587244
Sun et al. (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep. 4:4934
PMID: 24816792
Frazão et al. (2013) Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci. 33:2807
PMID: 23407940
Niu et al. (2011) Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition. Neuroscience. 180:344
PMID: 21296645

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Product Documents for Diazoxide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Diazoxide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov