Deguelin

Name: Deguelin
Brand: Tocris Bioscience
SKU: 1770

Tocris Bioscience a Bio-Techne Brand

Catalog # 1770

Citations (2)

COA / SDS

Discontinued Product

1770 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description:	Anticancer and antiviral agent; chemopreventive and pro-apoptotic
Chemical Name:	(7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
Purity:	≥97% (HPLC)
Molecular Weight:	394.42

View Full Technical Details for Deguelin

Biological Activity for Deguelin

Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC₅₀ values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.

Technical Data for Deguelin

M. Wt	394.42
Formula	C₂₃H₂₂O₆
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	522-17-8
PubChem ID	107935
InChi Key	ORDAZKGHSNRHTD-UXHICEINSA-N
Smiles	O=C(C(C=CC5=C4C=CC(C)(C)O5)=C4O3)[C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Deguelin

Solubility

Soluble Soluble to 50 mM in ethanol and to 100 mM in DMSO

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References for Deguelin

References are publications that support the biological activity of the product.

Chun Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J.Natl.Cancer Inst. 2003 PMID: 12591985
Fang and Casida Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9520374
Udeani Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 1997 PMID: 9270008
Takatsuki Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses. Appl.Microbiol. 1969 PMID: 4312925

Citations for Deguelin (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Deguelin include:

Hafeez et al. (2016) BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. J Neurosci. 11:e0145780
PMID: 26745145
Rebolleda et al. (2016) Synergistic Activity of Deguelin and fludar. in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS One. 11:e0154159
PMID: 27101369

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