d[Cha⁴]-AVP

Name: d[Cha 4 ]-AVP
Brand: Tocris Bioscience
SKU: 3126

Tocris Bioscience a Bio-Techne Brand

Catalog # 3126

Citations (1)

COA / SDS

Discontinued Product

3126 has been discontinued. View all Vasopressin Receptor Agonists products.

Key Product Details

Description:	Potent and selective human V_1B agonist
Molecular Weight:	1094.31

View Full Technical Details for d[Cha⁴]-AVP

Biological Activity for d[Cha⁴]-AVP

d[Cha⁴]-AVP is a potent and selective human vasopressin V_1B receptor agonist (K_i values are 1.2, 151, 240 and 750 nM for V_1B, V_1A, Oxytocin and V₂ receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.

Technical Data for d[Cha⁴]-AVP

M. Wt	1094.31
Formula	C₅₀H₇₁N₁₃O₁₁S₂
Single Letter Sequence	XYFXNCPRG (Modifications: X-1 = Mpr, X-4 = Cha, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)
Storage	Store at -20°C
CAS Number	500170-27-4
PubChem ID	44419028
InChi Key	ZKYCVZNKBXGNEK-ZTYVOHGWSA-N
Smiles	NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for d[Cha⁴]-AVP

Solubility

Soluble Soluble to 1 mg/ml in water

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References for d[Cha⁴]-AVP

References are publications that support the biological activity of the product.

Pena Design and synthesis of the frist selective agonists for the rat vasopressin V_1b receptor: based on modifications of deamino-[cys¹]arginine vasopressin at positions 4 and 8. J.Med.Chem. 2007 PMID: 17300166
Cheng Design of potent and selective agonists for the human vasopressin V_1b receptor based on modifications of [deamino-cys¹]arginine vasopressin at position 4. J.Med.Chem. 2004 PMID: 15084136
Derick [1-Deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V_1b receptors. Endocrinology 2002 PMID: 12446593

Citations for d[Cha⁴]-AVP (1)

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Citations are publications that use Bio-Techne products. Selected citations for d[Cha⁴]-AVP include:

Perígolo-Vicente et al. (2014) IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun. 449:477
PMID: 24845382

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Product Documents for d[Cha⁴]-AVP

COA

Certificate of Analysis

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d[Cha⁴]-AVP

Tocris Bioscience a Bio-Techne Brand

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Product Documents for d[Cha⁴]-AVP

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d[Cha4]-AVP

Tocris Bioscience a Bio-Techne Brand

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References for d[Cha4]-AVP

Citations for d[Cha4]-AVP (1)

Product Documents for d[Cha4]-AVP

COA

Certificate of Analysis

SDS

Bio-Techne Brands

d[Cha⁴]-AVP

Biological Activity for d[Cha⁴]-AVP

Technical Data for d[Cha⁴]-AVP

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References for d[Cha⁴]-AVP

Citations for d[Cha⁴]-AVP (1)

Product Documents for d[Cha⁴]-AVP