DBeQ

Tocris Bioscience, part of Bio-Techne | Catalog # 4417

Selective and reversible p97 ATPase inhibitor
Discontinued Product
4417 has been discontinued. View all Other ER Stress/UPR Inhibitors products.

Key Product Details

Description

Selective and reversible p97 ATPase inhibitor

View all Other ER Stress/UPR Inhibitors »

Product Description

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Product Specifications

Molecular Weight

340.42

Formula

C22H20N4

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

CAS Number

177355-84-9

PubChem ID

676352

InChI Key

QAIMUUJJAJBPCL-UHFFFAOYSA-N

SMILES

C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.04 100

Preparing Stock Solutions for DBeQ

The following data is based on the product molecular weight 340.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for DBeQ

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DBeQ

For research use only

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