DBeQ

Name: DBeQ
Brand: Tocris Bioscience
SKU: 4417
Rating: 3 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4417

Citations (1)

(1)

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Key Product Details

Description:	Selective and reversible p97 ATPase inhibitor
Chemical Name:	N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Purity:	≥99% (HPLC)
Molecular Weight:	340.42

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Biological Activity for DBeQ

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC₅₀ = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Compound Libraries for DBeQ

DBeQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DBeQ

M. Wt	340.42
Formula	C₂₂H₂₀N₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	177355-84-9
PubChem ID	676352
InChi Key	QAIMUUJJAJBPCL-UHFFFAOYSA-N
Smiles	C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DBeQ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.04	100

Preparing Stock Solutions for DBeQ

The following data is based on the product molecular weight 340.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.38 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Reconstitution Calculator

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References for DBeQ

References are publications that support the biological activity of the product.

Chou Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 2011 PMID: 21383145
Chou and Deshaies Development of p97 AAA ATPase inhibitors. Autophagy 2011 PMID: 21606684

Citations for DBeQ (1)

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Citations are publications that use Bio-Techne products. Selected citations for DBeQ include:

Tiwari et al. (2016) Caveolin-1 is an aggresome-inducing protein. Sci Rep. 6:38681
PMID: 27929047

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DbeQ on Dictyostelium mTORC1 signalling

Name: Eleanor Warren

Species: Other

Assay Type: In Vitro

Treated Dictyostelium cells with DbeQ at 15 uM and 1.5 uM concentrations for 1 hour or 24 hours, and monitored p-4E-BP1 levels as a readout for mTORc1 activity. Did not see any significant difference from control

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