[D-Trp^7,9,10]-Substance P

Name: [D-Trp 7,9,10 ]-Substance P
Brand: Tocris Bioscience
SKU: 1884

Tocris Bioscience, part of Bio-Techne | Catalog # 1884

Citations (8)

COA / SDS

Inhibits M1 ACh receptor activation of Gq/11

Discontinued Product

1884 has been discontinued. View all G Protein (Heterotrimeric) Inhibitors products.

Key Product Details

Description:	Inhibits M₁ ACh receptor activation of G_q/11
Alternative Names:	GPAnt-2 analog
Molecular Weight:	1588.89

View Full Technical Details for [D-Trp^7,9,10]-Substance P

Technical Data
Citations

Biological Activity for [D-Trp^7,9,10]-Substance P

[D-Trp^7,9,10]-Substance P is a substance P analog that inhibits activation of G_q/11 by M₁ muscarinic ACh receptors. Does not inhibit G_i/o activation by M₂ ACh receptors.

Technical Data for [D-Trp^7,9,10]-Substance P

M. Wt	1588.89
Formula	C₇₉H₁₀₅N₂₁O₁₃S
Single Letter Sequence	RPKPQQWFWWM (Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)
Storage	Store at -20°C
CAS Number	89430-38-6
PubChem ID	16143852
InChi Key	ZDXXOQXJCDHSRG-GGDSLUOHSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for [D-Trp^7,9,10]-Substance P

References are publications that support the biological activity of the product.

Mukai G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 1992 PMID: 1379592

[D-Trp^7,9,10]-Substance P

Tocris Bioscience, part of Bio-Techne | Catalog # 1884

Key Product Details

Biological Activity for [D-Trp^7,9,10]-Substance P

Technical Data for [D-Trp^7,9,10]-Substance P

Molarity Calculator

Dilution Calculator

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References for [D-Trp^7,9,10]-Substance P

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[D-Trp7,9,10]-Substance P

Tocris Bioscience, part of Bio-Techne | Catalog # 1884

Key Product Details

Biological Activity for [D-Trp7,9,10]-Substance P

Technical Data for [D-Trp7,9,10]-Substance P

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Trp7,9,10]-Substance P

Product Documents for [D-Trp7,9,10]-Substance P

COA

Certificate of Analysis

SDS

[D-Trp^7,9,10]-Substance P

Biological Activity for [D-Trp^7,9,10]-Substance P

Technical Data for [D-Trp^7,9,10]-Substance P

References for [D-Trp^7,9,10]-Substance P

Product Documents for [D-Trp^7,9,10]-Substance P