(d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

Name: (d(CH 2 ) 5 1 ,Tyr(Me) 2 ,Arg 8 )-Vasopressin
Brand: Tocris Bioscience
SKU: 3377

Catalog # 3377 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Selective vasopressin V1A antagonist

Key Product Details

Description:	Selective vasopressin V_1A antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1151.38

View Full Technical Details for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

Technical Data
Citations (1) / Reviews

Biological Activity

(d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin is a selective vasopressin V_1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC₅₀ values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.

Technical Data

M. Wt	1151.38
Formula	C₅₂H₇₄N₁₄O₁₂S₂
Single Letter Sequence	XYFQNCPRG (Modifications: X = Pmp, Tyr-2 = Tyr(Me), Disulfide bridge: 1-6, Gly-9 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	73168-24-8
PubChem ID	122173055
InChi Key	QVQOGNOOAMQKCE-LOVRMFBOSA-N
Smiles	COC1=CC=C(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC2=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 2mg/ml in water

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References

References are publications that support the biological activity of the product.

Engin and Treit Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus. Neuropeptides 2008 PMID: 18508119
Tsuchiya Vasopressin inhibits sarcolemmal ATP-sensitive K⁺ channels via V₁ receptors activation in the guinea pig heart. Circ.J. 2002 PMID: 11922278
Spath Arginine vasopressin and oxyt. increase intracellular calcium and cAMP in human glomerular epithelial cells in culture. Kidney Blood Press.Res. 1996 PMID: 8871886
Kruszynski [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vas J.Med.Chem. 1980 PMID: 6892930

Citations for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin (1)

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Citations are publications that use Bio-Techne products. Selected citations for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin include:

Campos-Lira et al. (2019) Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors. Front Neurosci. 12:919
PMID: 30618551

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Product Documents

COA

Certificate of Analysis

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(d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

Catalog # 3377 | Tocris Bioscience a Bio-Techne Brand

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin (1)

Product Documents

COA

Certificate of Analysis

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(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

Catalog # 3377 | Tocris Bioscience a Bio-Techne Brand

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (1)

Product Documents

COA

Certificate of Analysis

SDS

Bio-Techne Brands

(d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

Citations for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin (1)