D-Aspartic acid

Name: D -Aspartic acid
Brand: tocris
SKU: 0213

Catalog # 0213

Citations (1)

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Key Product Details

Description:	NMDA agonist
Chemical Name:	D-Aminosuccinic acid
Molecular Weight:	133.1

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Biological Activity

Endogenous NMDA receptor agonist with similar activity to the L-isomer. Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.

L-isomer also available.

Technical Data

M. Wt	133.1
Formula	C₄H₇NO₄
Storage	Store at RT
CAS Number	1783-96-6
PubChem ID	83887
InChi Key	CKLJMWTZIZZHCS-UWTATZPHSA-N
Smiles	N[C@@]([H])([C@](O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 133.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.51 mL	37.57 mL	75.13 mL
5 mM	1.50 mL	7.51 mL	15.03 mL
10 mM	0.75 mL	3.76 mL	7.51 mL
50 mM	0.15 mL	0.75 mL	1.50 mL

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References

References are publications that support the biological activity of the product.

Hashimoto Free D-aspartate and D-serine in the mammalian brain and periphery. Prog.Neurobiol. 1997 PMID: 9247969
Ishio D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neurosci.Lett. 1998 PMID: 9682837
Olverman Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes. Neuroscience 1988 PMID: 2901691

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for D-Aspartic acid include:

Cai and Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep. 25:3148
PMID: 30540946

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Product Datasheets

COA

Certificate of Analysis

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D-Aspartic acid

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Key Product Details

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Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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