Clofibrate

Name: Clofibrate
Brand: Tocris Bioscience
SKU: 0824

Catalog # 0824

COA / SDS

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	PPAR agonist
Chemical Name:	Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
Molecular Weight:	242.702

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Biological Activity

Clofibrate is a PPAR agonist (EC₅₀ values are 50, 500 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Antihyperlipoproteinemic.

Technical Data

M. Wt	242.702
Formula	C₁₂H₁₅ClO₃
Storage	Store at RT
CAS Number	637-07-0
PubChem ID	2796
InChi Key	KNHUKKLJHYUCFP-UHFFFAOYSA-N
Smiles	ClC1=CC=C(OC(C)(C)C(OCC)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.27	100

Preparing Stock Solutions

The following data is based on the product molecular weight 242.702.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.12 mL	20.60 mL	41.20 mL
5 mM	0.82 mL	4.12 mL	8.24 mL
10 mM	0.41 mL	2.06 mL	4.12 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Bishop-Bailey Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 2000 PMID: 10696077
Willson The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 2000 PMID: 10691680
Shepherd Mechanism of action of fibrates. Postgrad.Med.J. 1993 PMID: 8497455

Citations for Clofibrate

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Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Clofibrate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov