CL 075

Name: CL 075
Brand: Tocris Bioscience
SKU: 6142

Tocris Bioscience, part of Bio-Techne | Catalog # 6142

Citations (3)

COA / SDS

TLR8 agonist

Discontinued Product

6142 has been discontinued. View all Toll-like Receptor Agonists products.

Key Product Details

Description:	TLR8 agonist
Chemical Name:	2-Propylthiazolo[4,5-c]quinolin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	243.33

View Full Technical Details for CL 075

Technical Data
Citations

Biological Activity for CL 075

CL 075 is a TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat. No. 4287).

Technical Data for CL 075

M. Wt	243.33
Formula	C₁₃H₁₃N₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	256922-53-9
PubChem ID	10198719
InChi Key	NFYMGJSUKCDVJR-UHFFFAOYSA-N
Smiles	CCCC1=NC2=C(N=C3C=CC=CC3=C2S1)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CL 075

References are publications that support the biological activity of the product.

Pang Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 2011 PMID: 21962237
Spranger Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 2010 PMID: 20511554
Gorden Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 2005 PMID: 15661881

CL 075

Tocris Bioscience, part of Bio-Techne | Catalog # 6142

Key Product Details

Biological Activity for CL 075

Technical Data for CL 075

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CL 075

Product Documents for CL 075

COA

Certificate of Analysis

SDS

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