CINPA 1

Name: CINPA 1
Brand: Tocris Bioscience
SKU: 5605

Tocris Bioscience, part of Bio-Techne | Catalog # 5605

Citations (8)

COA / SDS

Potent CAR antagonist

Discontinued Product

5605 has been discontinued. View all Constitutive Androstane Receptor Antagonists products.

Key Product Details

Description:	Potent CAR antagonist
Chemical Name:	Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	395.49

View Full Technical Details for CINPA 1

Technical Data
Citations

Biological Activity for CINPA 1

CINPA 1 is a potent CAR antagonist (IC₅₀ = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.

Compound Libraries for CINPA 1

CINPA 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CINPA 1

M. Wt	395.49
Formula	C₂₃H₂₉N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	102636-74-8
PubChem ID	969470
InChi Key	AYQBYSPEGRYKFA-UHFFFAOYSA-N
Smiles	O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CINPA 1

References are publications that support the biological activity of the product.

Cherian CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 2015 PMID: 25762023