Cinanserin hydrochloride

Name: Cinanserin hydrochloride
Brand: Tocris Bioscience
SKU: 0460

Catalog # 0460 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

Selective 5-HT2 antagonist; also 3C-like proteinase inhibitor

Key Product Details

Description:	Selective 5-HT₂ antagonist; also 3C-like proteinase inhibitor
Chemical Name:	N-[2-[[3-(Dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	376.94

View Full Technical Details for Cinanserin hydrochloride

Technical Data
Citations (3) / Reviews

Biological Activity for Cinanserin hydrochloride

Cinanserin hydrochloride is a 5-HT₂ antagonist. Also inhibits 3C-like proteinase (3CL^pro; M^pro). Inhibits replication of SARS-CoV.

Technical Data for Cinanserin hydrochloride

M. Wt	376.94
Formula	C₂₀H₂₄N₂OS.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	54-84-2
PubChem ID	6433141
InChi Key	LXGJPDKYMJJWRB-IERUDJENSA-N
Smiles	O=C(/C=C/C2=CC=CC=C2)NC1=CC=CC=C1SCCCN(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cinanserin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		50

Preparing Stock Solutions for Cinanserin hydrochloride

The following data is based on the product molecular weight 376.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.31 mL	26.53 mL	53.06 mL
2.5 mM	1.06 mL	5.31 mL	10.61 mL
5 mM	0.53 mL	2.65 mL	5.31 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

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References for Cinanserin hydrochloride

References are publications that support the biological activity of the product.

Chen Cinanserin is an inhibitor of the 3C-like proteinase of the severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J.Virol. 2005 PMID: 15890949
Pierce Molecular structure basis of ligand selectivity for 5-HT₂ versus 5-HT_1C cortical receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1992 PMID: 1407003
Leysen Receptor binding profile of R-41-468, a novel antagonist at 5HT₂ receptors. Life Sci. 1981 PMID: 6261070

Citations for Cinanserin hydrochloride (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Cinanserin hydrochloride include:

Gautam et al. (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 15:75
PMID: 27871326
Buznikov et al. (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci. 32:1
PMID: 19907129
Seeburg et al. (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci. 24:10950
PMID: 15574745

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