CIMBA hydrochloride

Name: CIMBA hydrochloride
Brand: Tocris Bioscience
SKU: 7812

Tocris Bioscience, part of Bio-Techne | Catalog # 7812

COA / SDS

Potent and selective G protein-coupled estrogen receptor (GPER) antagonist

Key Product Details

Description:	Potent and selective G protein-coupled estrogen receptor (GPER) antagonist
Chemical Name:	N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-4-methoxybenzenemethanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	373.97

View Full Technical Details for CIMBA hydrochloride

Technical Data
Citations

Biological Activity for CIMBA hydrochloride

CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC₅₀ = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.

Licensing Information

Sold under licence from Saint Louis University.

Technical Data for CIMBA hydrochloride

M. Wt	373.97
Formula	C₂₃H₃₁NO.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	KWVXXQOTMDKOID-UHFFFAOYSA-N
Smiles	CC(C)C(C=C1C2CCCCC2)=CC=C1NCC(C=C3)=CC=C3OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CIMBA hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.4	100
	ethanol	37.4	100

Preparing Stock Solutions for CIMBA hydrochloride

The following data is based on the product molecular weight 373.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.37 mL	26.74 mL
5 mM	0.53 mL	2.67 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CIMBA hydrochloride

References are publications that support the biological activity of the product.

DeLeon A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 2020 PMID: 32127396