Chetomin

Tocris Bioscience, part of Bio-Techne | Catalog # 4705

Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
Discontinued Product
4705 has been discontinued. View all HIF Inhibitors products.

Key Product Details

Description

Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300

View all HIF Inhibitors »

Product Description

Chetomin is a targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro.

Product Specifications

Molecular Weight

710.87

Formula

C31H30N6O6S4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazinopyrrolo[2,3-b]indole-1,4-dione

CAS Number

1403-36-7

PubChem ID

90488965

InChI Key

ZRZWBWPDBOVIGQ-KIDIPURZSA-N

SMILES

CN(C([C@@](CO)7N(C)C3=O)=O)[C@]3(SS7)CC2=CN([C@@]5(C[C@@](SS9)6C8=O)C4=CC=CC=C4N[C@@]([H])5N6C([C@@](CO)9N8C)=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Chetomin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Chetomin

For research use only

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