cGMP Dependent Kinase Inhibitor Peptide

Name: cGMP Dependent Kinase Inhibitor Peptide
Brand: Tocris Bioscience
SKU: 1883
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1883

(1)

COA / SDS

Inhibitor of protein kinases G and A

Discontinued Product

1883 has been discontinued. View all Protein Kinase A Inhibitors products.

Key Product Details

Description:	Inhibitor of protein kinases G and A
Alternative Names:	[Ala³²]H2B(29-35)
Molecular Weight:	943.12

View Full Technical Details for cGMP Dependent Kinase Inhibitor Peptide

Technical Data
Citations / Reviews (1)

Biological Activity for cGMP Dependent Kinase Inhibitor Peptide

cGMP Dependent Kinase Inhibitor Peptide is a competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (K_i = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.

Technical Data for cGMP Dependent Kinase Inhibitor Peptide

M. Wt	943.12
Formula	C₃₈H₇₄N₁₈O₁₀
Single Letter Sequence	RKRARKE
Storage	Desiccate at -20°C
CAS Number	82801-73-8
PubChem ID	134097
InChi Key	OUKSKNTVYYVIMZ-DUJSLOSMSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for cGMP Dependent Kinase Inhibitor Peptide

References are publications that support the biological activity of the product.

Glass Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors. Biochem.J. 1983 PMID: 6615418
Glass Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J.Biol.Chem. 1986 PMID: 3017964
Bhatnagar Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry 1988 PMID: 2837278

cGMP Dependent Kinase Inhibitor Peptide

Tocris Bioscience, part of Bio-Techne | Catalog # 1883

Key Product Details

Biological Activity for cGMP Dependent Kinase Inhibitor Peptide

Technical Data for cGMP Dependent Kinase Inhibitor Peptide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for cGMP Dependent Kinase Inhibitor Peptide

Product Documents for cGMP Dependent Kinase Inhibitor Peptide

COA

Certificate of Analysis

SDS

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