Cercosporamide

Name: Cercosporamide
Brand: Tocris Bioscience
SKU: 4500

Tocris Bioscience a Bio-Techne Brand

Catalog # 4500

Citations (1)

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Key Product Details

Description:	Potent Mnk2 inhibitor
Chemical Name:	(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide
Purity:	≥96% (HPLC)
Molecular Weight:	331.28

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Biological Activity for Cercosporamide

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC₅₀ values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.

Technical Data for Cercosporamide

M. Wt	331.28
Formula	C₁₆H₁₃NO₇
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	131436-22-1
PubChem ID	131379
InChi Key	GEWLYFZWVLXQME-MRXNPFEDSA-N
Smiles	OC1=CC(O)=C(C(N)=O)C3=C1[C@@]2(C)C(O3)=CC(O)=C(C(C)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cercosporamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.31	10

Preparing Stock Solutions for Cercosporamide

The following data is based on the product molecular weight 331.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.19 mL	150.93 mL	301.86 mL
0.5 mM	6.04 mL	30.19 mL	60.37 mL
1 mM	3.02 mL	15.09 mL	30.19 mL
5 mM	0.60 mL	3.02 mL	6.04 mL

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References for Cercosporamide

References are publications that support the biological activity of the product.

Hou Targeting Mnks for cancer therapy. Oncotarget 2012 PMID: 22392765
Konicek Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 2011 PMID: 21233335
Sussman Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot.Cell 2004 PMID: 15302826

Citations for Cercosporamide (1)

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Citations are publications that use Bio-Techne products. Selected citations for Cercosporamide include:

Westergard et al. (2019) Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med. 11
PMID: 30617154

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