Celecoxib

Name: Celecoxib
Brand: Tocris Bioscience
SKU: 3786

Tocris Bioscience a Bio-Techne Brand

Catalog # 3786

Citations (2)

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Key Product Details

Description:	Selective cyclooxygenase-2 (COX-2) inhibitor
Alternative Names:	SC 58635, Celebrex
Chemical Name:	4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	381.37

View Full Technical Details for Celecoxib

Biological Activity for Celecoxib

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC₅₀ values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Celecoxib is an anti-inflammatory with shorter plasma half-life in vivo than SC 58121. Displays chemopreventive activity in in vivo tumor models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Celecoxib

Celecoxib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Celecoxib

M. Wt	381.37
Formula	C₁₇H₁₄F₃N₃O₂S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	169590-42-5
PubChem ID	2662
InChi Key	RZEKVGVHFLEQIL-UHFFFAOYSA-N
Smiles	CC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Celecoxib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.53	25
	ethanol	19.07	50

Preparing Stock Solutions for Celecoxib

The following data is based on the product molecular weight 381.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.24 mL	26.22 mL	52.44 mL
2.5 mM	1.05 mL	5.24 mL	10.49 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
25 mM	0.10 mL	0.52 mL	1.05 mL

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Reconstitution Calculator

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References for Celecoxib

References are publications that support the biological activity of the product.

Harris Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 2000 PMID: 10786667
DeWitt Cox-2-selective Inhibitors: the new super aspirins. Mol.Pharmacol. 1999 PMID: 10101019
Penning Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J.Med.Chem. 1997 PMID: 9135032

Citations for Celecoxib (2)

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Citations are publications that use Bio-Techne products. Selected citations for Celecoxib include:

Bowler et al. (2019) CXB Is Associated With Dystrophic Calcification and Aortic Valve Stenosis. JACC Basic Transl Sci. 4:135
PMID: 31061914
Oguh-Olayinka et al. (2019) The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2019;
PMID: 30941737

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