CB 13

Tocris Bioscience a Bio-Techne Brand

Catalog # 2928

Citations (2)

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Key Product Details

Description:	Potent dual CB₁/CB₂ agonist
Chemical Name:	1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone
Purity:	≥99% (HPLC)
Molecular Weight:	368.47

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Biological Activity for CB 13

CB 13 is a potent, orally active CB₁/CB₂ receptor agonist with limited brain penetration (EC₅₀ values are 6.1 and 27.9 nM for CB₁ and CB₂ receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.

Technical Data for CB 13

M. Wt	368.47
Formula	C₂₆H₂₄O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	432047-72-8
PubChem ID	9799417
InChi Key	RSUMDJRTAFBISX-UHFFFAOYSA-N
Smiles	O=C(C3=CC=CC4=C3C=CC=C4)C2=CC=C(OCCCCC)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CB 13

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.85	100
	ethanol	18.42	50

Preparing Stock Solutions for CB 13

The following data is based on the product molecular weight 368.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.57 mL	27.14 mL
5 mM	0.54 mL	2.71 mL	5.43 mL
10 mM	0.27 mL	1.36 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for CB 13

References are publications that support the biological activity of the product.

Cluny Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB₁/CB₂ receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. J.Pharmacol.Exp.Ther. 2010 PMID: 20571060
Dziadulewicz Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB₁/CB₂ dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J.Med.Chem. 2007 PMID: 17630726

Citations for CB 13 (2)

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Citations are publications that use Bio-Techne products. Selected citations for CB 13 include:

Alvarez-Fuentes et al. (2012) Development and validation of an RP-HPLC method for CB13 evaluation in several PLGA nanoparticle systems. ScientificWorldJournal. 2012:737526
PMID: 22792051
Godlewski et al. (2010) Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chem Biol. 17:1256
PMID: 21095576

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