Caspase Inhibitor Control Z-FA-FMK

Name: Caspase Inhibitor Control Z-FA-FMK
Brand: R&D Systems
SKU: FMKC01

R&D Systems, Inc. a Bio-Techne Brand

Catalog # FMKC01

Citations (3)

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Setting the standard in quality research reagents

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Citations (3) / Reviews

Summary for Caspase Inhibitor Control Z-FA-FMK

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Product Specifications for Caspase Inhibitor Control Z-FA-FMK

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Multi-Species

Preparation & Storage

Shipping Conditions	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Citations for Caspase Inhibitor Control Z-FA-FMK (3)

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Citations are publications that use Bio-Techne products. Selected citations for Caspase Inhibitor Control Z-FA-FMK include:

Species: Human
Sample Types: Whole Cells
Applications: Control

MJ Mitchell et al. (2017), Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis Nat Commun, 8(0):14179.
PMID: 28317839
Species: Human
Sample Types: Whole Cells

Teigler J et al. (2014), Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity. J Virol, 88(18):10354-63.
PMID: 24991003
Species: Human
Sample Types: Whole Cells

(2012), dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ., 19(9):1482-94.
PMID: 22421964

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Caspase Inhibitor Control Z-FA-FMK

R&D Systems, Inc. a Bio-Techne Brand

Key Product Details

Summary for Caspase Inhibitor Control Z-FA-FMK

Product Specifications for Caspase Inhibitor Control Z-FA-FMK

Preparation & Storage

Citations for Caspase Inhibitor Control Z-FA-FMK (3)

Product Documents for Caspase Inhibitor Control Z-FA-FMK

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