c-Di-AMP sodium salt

Name: c-Di-AMP sodium salt
Brand: Tocris Bioscience
SKU: 5901
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5901

(1)

COA / SDS

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Key Product Details

Description:	Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Chemical Name:	3',5'-Cyclic diadenylic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	702.38

View Full Technical Details for c-Di-AMP sodium salt

Technical Data
Citations / Reviews (1)

Biological Activity for c-Di-AMP sodium salt

c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A_2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34⁺ cells.

This product is sold in units of 702μg, equivalent to 1μmol.

Technical Data for c-Di-AMP sodium salt

M. Wt	702.38
Formula	C₂₀H₂₂N₁₀Na₂O₁₂P₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2734909-87-4
PubChem ID	11158091
InChi Key	PDXMFTWFFKBFIN-XPWFQUROSA-N
Smiles	O=P(O[C@H]1[C@H]([C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CO4)O)(O[Na])OC[C@@H]5[C@H]([C@H]([C@H](N6C=NC7=C6N=CN=C7N)O5)O)OP4(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for c-Di-AMP sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	14.05	20

Preparing Stock Solutions for c-Di-AMP sodium salt

The following data is based on the product molecular weight 702.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	7.12 mL	35.59 mL	71.19 mL
1 mM	1.42 mL	7.12 mL	14.24 mL
2 mM	0.71 mL	3.56 mL	7.12 mL
10 mM	0.14 mL	0.71 mL	1.42 mL

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References for c-Di-AMP sodium salt

References are publications that support the biological activity of the product.

Tosolini Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A_2a G_αs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol.Cell.Biol. 2015 PMID: 25384972
Parvatiyar The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 2012 PMID: 23142775