C 646

Name: C 646
Brand: Tocris Bioscience
SKU: 4200
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4200

(1)

Citations (24)

COA / SDS

p300/CBP inhibitor

Discontinued Product

4200 has been discontinued. View all Other Transferase Inhibitors products.

Key Product Details

Description:	p300/CBP inhibitor
Chemical Name:	4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	445.42

View Full Technical Details for C 646

Technical Data
Citations / Reviews (1)

Biological Activity for C 646

C 646 is a p300/CREB-binding protein (CBP) inhibitor (K_i = 400 nM). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines. Also represses pluripotency markers in mouse embryonic stem cells. Newer p300 probes are also available: iP300w (Cat. No. 7270) and A 485 (Cat. No. 6387).

This compound is a mixture of Z:E isomers (~ 80:20).

Technical Data for C 646

M. Wt	445.42
Formula	C₂₄H₁₉N₃O₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	328968-36-1
PubChem ID	1285941
InChi Key	HEKJYZZSCQBJGB-UNOMPAQXSA-N
Smiles	CC/2=NN(C(C2=C/C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)=O)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for C 646

References are publications that support the biological activity of the product.

Dahlin Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nat.Commun. 2017 PMID: 29142305
Dan Roles for histone acetylation in regulation of telomere elongation and two-cell state in mouse ES cells. J.Cell.Physiol. 2015 PMID: 25752831
Crump Dynamic acetylation of all lysine-4 trimethylated histone H₃ is evolutionarily conserved and mediated by p300/CBP. Proc.Natl.Acad.Sci. USA
Ott and Verdi HAT trick: p300, small molecule, inhibitor. Chem.Biol. 2010 PMID: 20534339
Mali Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 2010 PMID: 20201064
Bowers Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem.Biol. 2010 PMID: 20534345

C 646

Tocris Bioscience, part of Bio-Techne | Catalog # 4200

Key Product Details

Biological Activity for C 646

Technical Data for C 646

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for C 646

Product Documents for C 646

COA

Certificate of Analysis

SDS

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