C 646

Tocris Bioscience, part of Bio-Techne | Catalog # 4200

p300/CBP inhibitor
Discontinued Product
4200 has been discontinued. View all Other Transferase Inhibitors products.

Key Product Details

Description

p300/CBP inhibitor

View all Other Transferase Inhibitors »

Product Description

C 646 is a p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines. Also represses pluripotency markers in mouse embryonic stem cells. Newer p300 probes are also available: iP300w (Cat. No. 7270) and A 485 (Cat. No. 6387).

This compound is a mixture of Z:E isomers (~ 80:20).

Product Specifications

Molecular Weight

445.42

Formula

C24H19N3O6

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

CAS Number

328968-36-1

PubChem ID

1285941

InChI Key

HEKJYZZSCQBJGB-UNOMPAQXSA-N

SMILES

CC/2=NN(C(C2=C/C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)=O)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.14 25

Preparing Stock Solutions for C 646

The following data is based on the product molecular weight 445.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.98 mL 44.90 mL 89.80 mL
1.25 mM 1.80 mL 8.98 mL 17.96 mL
2.5 mM 0.90 mL 4.49 mL 8.98 mL
12.5 mM 0.18 mL 0.90 mL 1.80 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for C 646

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for C 646

For research use only

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