BYK 191023 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2866
Potent and selective inhibitor of iNOS
Discontinued Product
2866 has been discontinued.
View all iNOS Inhibitors products.
Product Description
BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.Licensing Information
Sold with the permission of NycomedProduct Specifications
Molecular Weight
327.21
Formula
C14H14N4O.2HCl
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride
CAS Number
1216722-25-6
PubChem ID
56972216
InChI Key
ZVNITETZYOKESF-UHFFFAOYSA-N
SMILES
COC1=CC(CCC2=NC(N=CC=C3)=C3N2)=NC=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.72 | 100 |
Preparing Stock Solutions
for BYK 191023 dihydrochloride
The following data is based on the product molecular weight 327.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.06 mL | 15.28 mL | 30.56 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.11 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.06 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Strub The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol.Pharmacol.
- Tiso BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol.Pharmacol.
- Lehner In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase. J.Pharmacol.Exp.Ther. 2006 PMID: 16368897
Product Specific Notices for BYK 191023 dihydrochloride
For research use only
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