BRD 7389
Tocris Bioscience, part of Bio-Techne | Catalog # 4037
Ribosomal S6 kinase inhibitor
Discontinued Product
4037 has been discontinued.
View all RSK Inhibitors products.
Product Description
BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.Product Specifications
Molecular Weight
366.41
Formula
C24H18N2O2
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
CAS Number
376382-11-5
PubChem ID
1080352
InChI Key
XASCINRGTHLHGM-UHFFFAOYSA-N
SMILES
O=C(C3=C2C(N4)=CC=C3)C1=CC=CC=C1C2=C(NCCC5=CC=CC=C5)C4=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.64 | 100 |
Preparing Stock Solutions
for BRD 7389
The following data is based on the product molecular weight 366.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.73 mL | 13.65 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.73 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fomina-Yadlin Small molecule inducers of Ins expression in pancreatic alpha cells. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 20696901
Product Specific Notices for BRD 7389
For research use only
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