BQCA

Name: BQCA
Brand: Tocris Bioscience
SKU: 6872

Tocris Bioscience, part of Bio-Techne | Catalog # 6872

COA / SDS

Positive allosteric modulator of M1 receptors

Discontinued Product

6872 has been discontinued. View all mAChR M1 Modulators products.

Key Product Details

Description:	Positive allosteric modulator of M₁ receptors
Chemical Name:	1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	309.32

View Full Technical Details for BQCA

Technical Data
Citations

Biological Activity for BQCA

BQCA is a muscarinic M₁ receptor positive allosteric modulator (pK_B 5.76 - 5.82). Exhibits selectivity for M₁ over M₃ and M₅ receptors. Enhances ACh effects at M₁ receptors in an IP₁- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M₁^-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.

Technical Data for BQCA

M. Wt	309.32
Formula	C₁₈H₁₅NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	338747-41-4
PubChem ID	1476756
InChi Key	BZBBTGCKPRSPGF-UHFFFAOYSA-N
Smiles	COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BQCA

References are publications that support the biological activity of the product.

Ma Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19717450
Khajehali Probing the binding site of novel selective positive allosteric modulators at the M₁ muscarinic acetylcholine receptor. Biochem.Pharmacol 2018 PMID: 29777683

BQCA

Tocris Bioscience, part of Bio-Techne | Catalog # 6872

Key Product Details

Biological Activity for BQCA

Technical Data for BQCA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BQCA

Product Documents for BQCA

COA

Certificate of Analysis

SDS

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