BQCA

Name: BQCA
Brand: Tocris Bioscience
SKU: 6872
Price: 113 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 6872

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Key Product Details

Description:	Positive allosteric modulator of M₁ receptors
Chemical Name:	1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	309.32

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Biological Activity for BQCA

BQCA is a muscarinic M₁ receptor positive allosteric modulator (pK_B 5.76 - 5.82). Exhibits selectivity for M₁ over M₃ and M₅ receptors. Enhances ACh effects at M₁ receptors in an IP₁- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M₁^-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.

Technical Data for BQCA

M. Wt	309.32
Formula	C₁₈H₁₅NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	338747-41-4
PubChem ID	1476756
InChi Key	BZBBTGCKPRSPGF-UHFFFAOYSA-N
Smiles	COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BQCA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.19	20 with gentle warming

Preparing Stock Solutions for BQCA

The following data is based on the product molecular weight 309.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.16 mL	80.82 mL	161.64 mL
1 mM	3.23 mL	16.16 mL	32.33 mL
2 mM	1.62 mL	8.08 mL	16.16 mL
10 mM	0.32 mL	1.62 mL	3.23 mL

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References for BQCA

References are publications that support the biological activity of the product.

Khajehali Probing the binding site of novel selective positive allosteric modulators at the M₁ muscarinic acetylcholine receptor. Biochem.Pharmacol 2018 PMID: 29777683
Ma Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19717450

Citations for BQCA

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