BQCA

Product Description

BQCA is a muscarinic M₁ receptor positive allosteric modulator (pK_B 5.76 - 5.82). Exhibits selectivity for M₁ over M₃ and M₅ receptors. Enhances ACh effects at M₁ receptors in an IP₁- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M₁^-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.

Solubility

Preparing Stock Solutions for BQCA

The following data is based on the product molecular weight 309.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.16 mL	80.82 mL	161.64 mL
1 mM	3.23 mL	16.16 mL	32.33 mL
2 mM	1.62 mL	8.08 mL	16.16 mL
10 mM	0.32 mL	1.62 mL	3.23 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ma Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19717450
• Khajehali Probing the binding site of novel selective positive allosteric modulators at the M₁ muscarinic acetylcholine receptor. Biochem.Pharmacol 2018 PMID: 29777683