BMS 599626 dihydrochloride

Name: BMS 599626 dihydrochloride
Brand: Tocris Bioscience
SKU: 5022

Tocris Bioscience, part of Bio-Techne | Catalog # 5022

COA / SDS

Potent, selective EGFR and ErbB2 inhibitor

Discontinued Product

5022 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description:	Potent, selective EGFR and ErbB2 inhibitor
Chemical Name:	(3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	603.48

View Full Technical Details for BMS 599626 dihydrochloride

Technical Data
Citations

Biological Activity for BMS 599626 dihydrochloride

BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC₅₀ values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC₅₀ = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Orally bioavailable.

Technical Data for BMS 599626 dihydrochloride

M. Wt	603.48
Formula	C₂₇H₂₇FN₈O₃.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1781932-33-9
PubChem ID	90488998
InChi Key	SKHKFWSXLCGMNF-IKXQUJFKSA-N
Smiles	FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C)C(NC(OC[C@@H]6COCCN6)=O)=C5)=C3)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BMS 599626 dihydrochloride

References are publications that support the biological activity of the product.

Gavai Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficaciou J.Med.Chem. 2009 PMID: 19821562
Wong Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin.Cancer Res. 2006 PMID: 17062696

BMS 599626 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5022

Key Product Details

Biological Activity for BMS 599626 dihydrochloride

Technical Data for BMS 599626 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BMS 599626 dihydrochloride

Product Documents for BMS 599626 dihydrochloride

COA

Certificate of Analysis

SDS

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