BMS 453 is a synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G₁ arrest.

Product Specifications

Molecular Weight

380.48

Formula

C₂₇H₂₄O₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid

CAS Number

166977-43-1

PubChem ID

9875424

InChI Key

VUODRPPTYLBGFM-CMDGGOBGSA-N

SMILES

CC(CC=C3C4=CC=CC=C4)(C)C(C3=C2)=CC=C2/C=C/C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.05	100

Preparing Stock Solutions for BMS 453

The following data is based on the product molecular weight 380.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.14 mL	26.28 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Background References

References are publications that support the biological activity of the product.

Yang The retinoic acid receptor antagonist, BMS543, inhibits normal breast cell growth by inducing active TGFB and causing cell cycle arrest. Oncogene 2001 PMID: 11753686
Monteiro Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3. Stem Cells Dev. 2009 PMID: 18690793
Chen RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 1995 PMID: 7720709

BMS 453

Tocris Bioscience, part of Bio-Techne | Catalog # 3409

Key Product Details

Description

Alternative Names

View all Additional Retinoic Acid Receptor Compounds »

Product Description