BMS 193885

Name: BMS 193885
Brand: Tocris Bioscience
SKU: 3242

Catalog # 3242 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Potent, competitive NPY Y1 receptor antagonist

Key Product Details

Description:	Potent, competitive NPY Y₁ receptor antagonist
Chemical Name:	1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate
Purity:	≥99% (HPLC)
Molecular Weight:	680.79

View Full Technical Details for BMS 193885

Technical Data
Citations (1) / Reviews

Biological Activity for BMS 193885

BMS 193885 is a potent, competitive neuropeptide (NPY) Y₁ antagonist (K_i = 3.3 nM, IC₅₀ = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ₁, α₁, Y₂, Y₄ and Y₅ receptors respectively. Reduces food intake and body weight via central Y₁ inhibition and is brain penetrant.

Technical Data for BMS 193885

M. Wt	680.79
Formula	C₃₃H₄₂N₄O₆.C₃H₆O₃
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	679839-66-8
PubChem ID	56972234
InChi Key	BYHJIPSVXAFCDI-WNQIDUERSA-N
Smiles	CC1=C(C(OC)=O)C(C2=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=CC=C2)C(C(OC)=O)=C(C)N1.C[C@H](O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 193885

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.62	20
	DMSO	68.08	100

Preparing Stock Solutions for BMS 193885

The following data is based on the product molecular weight 680.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.47 mL	7.34 mL	14.69 mL
5 mM	0.29 mL	1.47 mL	2.94 mL
10 mM	0.15 mL	0.73 mL	1.47 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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References for BMS 193885

References are publications that support the biological activity of the product.

Antal-Zimanyi Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist Eur.J.Pharmacol. 2008 PMID: 18573246
Poindexter Dihydropyridine neuropeptide Y Y₁ receptor antagonists 2: bioisosteric urea replacements Bioorg.Med.Chem. 2004 PMID: 14723969
Poindexter Dihydropyridine neuropeptide Y Y₁ receptor antagonists. Bioorg.Med.Chem.Letts.

Citations for BMS 193885 (1)

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Citations are publications that use Bio-Techne products. Selected citations for BMS 193885 include:

Acton et al. (2019) Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep. 28:625
PMID: 31315043

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