BAY 8002

Name: BAY 8002
Brand: Tocris Bioscience
SKU: 6817

Tocris Bioscience, part of Bio-Techne | Catalog # 6817

Citations (2)

COA / SDS

Potent dual MCT1/2 inhibitor; orally bioavailable

Discontinued Product

6817 has been discontinued. View all Monocarboxylate Transporter Inhibitors products.

Key Product Details

Description:	Potent dual MCT1/2 inhibitor; orally bioavailable
Chemical Name:	2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	415.85

View Full Technical Details for BAY 8002

Technical Data
Citations

Biological Activity for BAY 8002

BAY 8002 is a potent dual MCT1/2 inhibitor (IC₅₀ values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively; IC₅₀ values of human MCT1, MCT2, and MCT4 isoforms recombinantly expressed in X. laevis oocytes are 1, 5 and >500 nM, respectively); suppresses bidirectional lactate transport. Inhibits cellular SNARF-5 fluorescence change (IC₅₀ = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in mice. Orally bioavailable.

Technical Data for BAY 8002

M. Wt	415.85
Formula	C₂₀H₁₄ClNO₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	724440-27-1
PubChem ID	992293
InChi Key	CLAUJSRBKSRTGQ-UHFFFAOYSA-N
Smiles	OC(C1=C(C=CC=C1)NC(C2=C(C=CC(S(=O)(C3=CC=CC=C3)=O)=C2)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BAY 8002

References are publications that support the biological activity of the product.

Quanz Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance. Mol.Cancer Ther. 2018 PMID: 30115664

BAY 8002

Tocris Bioscience, part of Bio-Techne | Catalog # 6817

Key Product Details

Biological Activity for BAY 8002

Technical Data for BAY 8002

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BAY 8002

Product Documents for BAY 8002

COA

Certificate of Analysis

SDS

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