Bay 59-3074

Name: Bay 59-3074
Brand: Tocris Bioscience
SKU: 2500

Tocris Bioscience, part of Bio-Techne | Catalog # 2500

Citations (1747)

COA / SDS

CB1/CB2 receptor partial agonist

Discontinued Product

2500 has been discontinued. View all Non-selective Cannabinoid Receptor Agonists products.

Key Product Details

Description:	CB₁/CB₂ receptor partial agonist
Chemical Name:	3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl 4,4,4-trifluoro-1-butanesulfonic acid ester
Purity:	≥99% (HPLC)
Molecular Weight:	453.35

View Full Technical Details for Bay 59-3074

Technical Data
Citations

Biological Activity for Bay 59-3074

Bay 59-3074 is a novel CB₁/CB₂ receptor partial agonist (K_i values are 48.3 and 45.5 nM at human CB₁ and CB₂ receptors respectively). Orally active CB₁ agonist in vivo. Displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain.

Licensing Information

Sold for research purposes under agreement from Bayer

Technical Data for Bay 59-3074

M. Wt	453.35
Formula	C₁₈H₁₃F₆NO₄S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	406205-74-1
PubChem ID	10479060
InChi Key	LWUSZIVDPJPVBW-UHFFFAOYSA-N
Smiles	FC(F)(F)CCCS(=O)(=O)OC1=CC(OC2=CC=CC(=C2C#N)C(F)(F)F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Bay 59-3074

References are publications that support the biological activity of the product.

De Vry Discriminative stimulus effects of the structurally novel cannabinoid CB₁/CB₂ receptor partial agonist BAY 59-3074 in the rat. Eur J Pharmacol. 2004 PMID: 15556145
De Vry 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid CB₁/CB₂ receptor partial agonist with antihyperalgesic and antiallodynic effects. J.Pharmacol.Exp.Ther. 2004 PMID: 15140913