β-Funaltrexamine hydrochloride

Name: β-Funaltrexamine hydrochloride
Brand: Tocris Bioscience
SKU: 0926
Price: 257 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0926

Citations (7)

COA / SDS

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Key Product Details

Description:	Irreversible and selective μ antagonist
Alternative Names:	β-FNA
Chemical Name:	(E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	490.99

View Full Technical Details for β-Funaltrexamine hydrochloride

Biological Activity for β-Funaltrexamine hydrochloride

β-Funaltrexamine hydrochloride is a selective μ opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data for β-Funaltrexamine hydrochloride

M. Wt	490.99
Formula	C₂₅H₃₀N₂O₆.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	72786-10-8
PubChem ID	44522395
InChi Key	BIPHUOBUKMPSQR-NQGXHZAGSA-N
Smiles	Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC[C@H]2NC(=O)\C=C\C(=O)OC)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for β-Funaltrexamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.82	20 with gentle warming
	DMSO	49.1	100

Preparing Stock Solutions for β-Funaltrexamine hydrochloride

The following data is based on the product molecular weight 490.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.18 mL	20.37 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for β-Funaltrexamine hydrochloride

References are publications that support the biological activity of the product.

Jiang μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 1990 PMID: 2156986
Takemorei The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltr. Eur.J.Pharmacol. 1981 PMID: 6263637

Citations for β-Funaltrexamine hydrochloride (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for β-Funaltrexamine hydrochloride include:

Crowley et al. (2020) Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ Opioid Receptor. ACS Chem Neurosci. 11:1781
PMID: 32383854
Chen et al. (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Neuropsychopharmacology. 10:e0145556
PMID: 26700862
Romero-Picó et al. (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Circulation. 38:1296
PMID: 23348063
Phillips et al. (2012) Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression. J Neurophysiol. 108:2393
PMID: 22956800
Tzeng et al. (2011) Myricetin Ameliorates Defective Post-Receptor Ins Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evid Based Complement Alternat Med. 2011:150752
PMID: 21785619
Largent-Milnes et al. (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol. 161:986
PMID: 20977451
Cecchi et al. (2008) Differential responses to morphine-induced analgesia in the tail-flick test. Behav Brain Res. 194:146
PMID: 18656501

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Showing 1 - 7 of 7 citations Showing All

Product Documents for β-Funaltrexamine hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.