AY 77

Tocris Bioscience a Bio-Techne Brand

Catalog # 7033

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Key Product Details

Description:	Potent PAR2 biased agonist; exhibits bias for Ca²⁺ signaling
Purity:	≥95% (HPLC)
Molecular Weight:	404.5

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Biological Activity for AY 77

AY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca²⁺ over ERK1/2 signaling (EC₅₀ values are 40 nM for Ca²⁺ release versus 2 μM for ERK1/2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cells in vitro.

Technical Data for AY 77

M. Wt	404.5
Formula	C₂₁H₃₂N₄O₄
Single Letter Sequence	XX (Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1835734-92-3
PubChem ID	137654325
InChi Key	CAYJNBJPGBBDAS-WMZOPIPTSA-N
Smiles	O=C(N[C@H](C(N[C@H](C(N)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AY 77

Solubility

Soluble to 1mg/ml in ethanol

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References for AY 77

References are publications that support the biological activity of the product.

Jiang Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 2017 PMID: 28169521
Yau Potent small agonists of protease activated receptor 2. ACS Med.Chem.Lett. 2015 PMID: 26819675

Citations for AY 77

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AY 77

Tocris Bioscience a Bio-Techne Brand

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References for AY 77

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Product Documents for AY 77

COA

Certificate of Analysis

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