ATC 0175 hydrochloride

Name: ATC 0175 hydrochloride
Brand: Tocris Bioscience
SKU: 3346

Tocris Bioscience, part of Bio-Techne | Catalog # 3346

COA / SDS

MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist

Discontinued Product

3346 has been discontinued. View all Melanin-concentrating Hormone Receptor Antagonists products.

Key Product Details

Description:	MCH₁ antagonist; also 5-HT_2B antagonist and 5-HT_1A partial agonist
Chemical Name:	N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	461.94

View Full Technical Details for ATC 0175 hydrochloride

Technical Data
Citations

Biological Activity for ATC 0175 hydrochloride

ATC 0175 hydrochloride is a potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH₁) antagonist (IC₅₀ values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT_2B and 5-HT_1A receptors (IC₅₀ values are 9.66 and 16.9 nM respectively).

Technical Data for ATC 0175 hydrochloride

M. Wt	461.94
Formula	C₂₃H₂₅F₂N₅O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	510733-97-8
PubChem ID	9934032
InChi Key	HUUPKFUYSQNNLO-UHFFFAOYSA-N
Smiles	O=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ATC 0175 hydrochloride

References are publications that support the biological activity of the product.

Chaki ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 PMID: 16614734
Chaki Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 2005 PMID: 15677346

ATC 0175 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3346

Key Product Details

Biological Activity for ATC 0175 hydrochloride

Technical Data for ATC 0175 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ATC 0175 hydrochloride

Product Documents for ATC 0175 hydrochloride

COA

Certificate of Analysis

SDS

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