Artemisinin

Name: Artemisinin
Brand: Tocris Bioscience
SKU: 2668

Tocris Bioscience a Bio-Techne Brand

Catalog # 2668

COA / SDS

Discontinued Product

2668 has been discontinued. View all Ca2+-ATPase Inhibitors products.

Key Product Details

Description:	Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
Alternative Names:	Qinghaosu
Chemical Name:	(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Purity:	≥99% (HPLC)
Molecular Weight:	282.33

View Full Technical Details for Artemisinin

Biological Activity for Artemisinin

Artemisinin is an antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (K_i ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

Technical Data for Artemisinin

M. Wt	282.33
Formula	C₁₅H₂₂O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	63968-64-9
PubChem ID	68827
InChi Key	BLUAFEHZUWYNDE-NNWCWBAJSA-N
Smiles	O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Artemisinin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.23	100
	ethanol	21.17	75

Preparing Stock Solutions for Artemisinin

The following data is based on the product molecular weight 282.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.71 mL	35.42 mL
5 mM	0.71 mL	3.54 mL	7.08 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Artemisinin

References are publications that support the biological activity of the product.

Eckstein-Ludwig Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003 PMID: 12931192
Wartenberg The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 2003 PMID: 14615418
Balint Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 2001 PMID: 11578659

Citations for Artemisinin

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.