Artemisinin

Tocris Bioscience, part of Bio-Techne | Catalog # 2668

Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
Discontinued Product
2668 has been discontinued. View all Ca2+-ATPase Inhibitors products.

Key Product Details

Description

Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum

Alternative Names

Qinghaosu

View all Ca2+-ATPase Inhibitors »

Product Description

Artemisinin is an antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

Product Specifications

Molecular Weight

282.33

Formula

C15H22O5

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

CAS Number

63968-64-9

PubChem ID

68827

InChI Key

BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES

O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.23 100
Ethanol 21.17 75

Preparing Stock Solutions for Artemisinin

The following data is based on the product molecular weight 282.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Artemisinin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Artemisinin

For research use only

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