AR-C 66096 tetrasodium salt is a potent and selective P2Y₁₂ receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pK_B =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC₅₀ = 8.16).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications

Molecular Weight

703.26

Formula

C₁₄H₁₈F₂N₅Na₄O₁₂P₃S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt

CAS Number

145782-74-7

PubChem ID

90488830

InChI Key

IETVOLFQZIGNAQ-HVYRMSERSA-J

SMILES

[Na+].[Na+].[Na+].[Na+].CCCSC1=NC(N)=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)[C@@H](O)[C@H]3O)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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Background References

References are publications that support the biological activity of the product.

Ingall Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 1999 PMID: 9925726
Simon Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells. Br.J.Pharmacol. 2001 PMID: 11156575
Humphries FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br.J.Pharmacol. 1994 PMID: 7858849

AR-C 66096 tetrasodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 3321

Key Product Details

Description

Alternative Names

View all P2Y Receptor Antagonists »

Product Description