Anagrelide hydrochloride

Name: Anagrelide hydrochloride
Brand: Tocris Bioscience
SKU: 2432

Tocris Bioscience a Bio-Techne Brand

Catalog # 2432

COA / SDS

Discontinued Product

2432 has been discontinued. View all Phosphodiesterase Inhibitors products.

Key Product Details

Description:	Potent PDE3 inhibitor
Alternative Names:	BL 4162A
Chemical Name:	6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	292.55

View Full Technical Details for Anagrelide hydrochloride

Biological Activity for Anagrelide hydrochloride

Anagrelide hydrochloride is a potent type III phosphodiesterase (PDE3) inhibitor (IC₅₀ = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

Technical Data for Anagrelide hydrochloride

M. Wt	292.55
Formula	C₁₀H₇Cl₂N₃O.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	58579-51-4
PubChem ID	42786
InChi Key	TVWRQCIPWUCNMI-UHFFFAOYSA-N
Smiles	ClC1=C(CN(C3)C(N2)=NC3=O)C2=CC=C1Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Anagrelide hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.93	10

Preparing Stock Solutions for Anagrelide hydrochloride

The following data is based on the product molecular weight 292.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.18 mL	170.91 mL	341.82 mL
0.5 mM	6.84 mL	34.18 mL	68.36 mL
1 mM	3.42 mL	17.09 mL	34.18 mL
5 mM	0.68 mL	3.42 mL	6.84 mL

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Reconstitution Calculator

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References for Anagrelide hydrochloride

References are publications that support the biological activity of the product.

Wang Comparison of the biological activities of anagr. and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 2005 PMID: 16041400
Mazur Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 1992 PMID: 1562721
Gillespie Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 1988 PMID: 2456068

Citations for Anagrelide hydrochloride

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