Amthamine dihydrobromide

Name: Amthamine dihydrobromide
Brand: Tocris Bioscience
SKU: 0668

Catalog # 0668

Citations (4)

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Key Product Details

Description:	Highly selective standard H₂ agonist
Chemical Name:	2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	319.06

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Biological Activity

Amthamine dihydrobromide is a highly selective H₂ agonist, slightly more potent than histamine itself. Only a weak antagonist at H₃ and has no activity at H₁ receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.

Technical Data

M. Wt	319.06
Formula	C₆H₁₁N₃S.2HBr
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	142457-00-9
PubChem ID	16218912
InChi Key	XFXNNOPUDSFVJE-UHFFFAOYSA-N
Smiles	Br.Br.CC1=C(CCN)SC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	31.91	100

Preparing Stock Solutions

The following data is based on the product molecular weight 319.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.67 mL	31.34 mL
5 mM	0.63 mL	3.13 mL	6.27 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References

References are publications that support the biological activity of the product.

Jarajapu Histamine decreases myogenic tone in rat cerebral arteries by H₂-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 2006 PMID: 16920098
Coruzzi The new potent and selective histamine H₂ receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 8377843
Poli In vitro cardiac pharmacology of the new histamine H₂ receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 1993 PMID: 8147269
Eriks Histamine H₂-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 1992 PMID: 1507209

Citations for Amthamine dihydrobromide (4)

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Citations are publications that use Bio-Techne products. Selected citations for Amthamine dihydrobromide include:

Saligrama et al. (2014) Histamine H₂ receptor signaling � environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J. 28:1898
PMID: 24371118
Copsel et al. (2011) Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem. 286:6979
PMID: 21205825
Chigaev et al. (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem. 286:20375
PMID: 21515675
Flamand et al. (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 141:552
PMID: 14744809

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