Amitriptyline hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4456

5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist
Discontinued Product
4456 has been discontinued. View all 5-HT Transporter Inhibitors products.

Key Product Details

Description

5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist

View all 5-HT Transporter Inhibitors »

Product Description

Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.

Product Specifications

Molecular Weight

313.86

Formula

C20H23N.HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride

CAS Number

549-18-8

PubChem ID

11065

InChI Key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

SMILES

CN(CC\C=C2/C3=C(C=CC=C3)CCC1=CC=CC=C12)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.39 100
DMSO 31.39 100

Preparing Stock Solutions for Amitriptyline hydrochloride

The following data is based on the product molecular weight 313.86

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Amitriptyline hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Amitriptyline hydrochloride

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.