Amitriptyline hydrochloride

Name: Amitriptyline hydrochloride
Brand: Tocris Bioscience
SKU: 4456

Tocris Bioscience a Bio-Techne Brand

Catalog # 4456

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Key Product Details

Description:	5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist
Chemical Name:	3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	313.86

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Biological Activity for Amitriptyline hydrochloride

Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenaline uptake; also activates α_2A-adrenoceptors and antagonizes 5-HT₂ receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.

Technical Data for Amitriptyline hydrochloride

M. Wt	313.86
Formula	C₂₀H₂₃N.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	549-18-8
PubChem ID	11065
InChi Key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
Smiles	CN(CC\C=C2/C3=C(C=CC=C3)CCC1=CC=CC=C12)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amitriptyline hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.39	100
	DMSO	31.39	100

Preparing Stock Solutions for Amitriptyline hydrochloride

The following data is based on the product molecular weight 313.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.19 mL	15.93 mL	31.86 mL
5 mM	0.64 mL	3.19 mL	6.37 mL
10 mM	0.32 mL	1.59 mL	3.19 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for Amitriptyline hydrochloride

References are publications that support the biological activity of the product.

Sawynok Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 2001 PMID: 11212590
Ghelardini Antinociception induced by amitript. and imipr. is mediated by α_2A-adrenoceptors. Jpn.J.Pharmacol. 2000 PMID: 10877531
Sanchez and Hyttel Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 1999 PMID: 10379421

Citations for Amitriptyline hydrochloride

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Amitriptyline hydrochloride

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Biological Activity for Amitriptyline hydrochloride

Technical Data for Amitriptyline hydrochloride

Solubility for Amitriptyline hydrochloride

Preparing Stock Solutions for Amitriptyline hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Amitriptyline hydrochloride

Citations for Amitriptyline hydrochloride

Product Documents for Amitriptyline hydrochloride

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