Amisulpride

Name: Amisulpride
Brand: Tocris Bioscience
SKU: 2132
Price: 153 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2132

Citations (2)

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Key Product Details

Description:	Selective D₂ and D₃ antagonist; atypical antipsychotic
Alternative Names:	DAN 2163
Chemical Name:	4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	369.48

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Biological Activity for Amisulpride

Amisulpride is a potent, selective dopamine D₂ and D₃ receptor antagonist. K_i values are 2.8 and 3.2 nM respectively for human D₂ and D₃ and > 1000 nM for human D₁, D₄ and D₅ receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D₂/D₃ receptors at higher doses. Preferentially interacts with limbic D₂-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

Technical Data for Amisulpride

M. Wt	369.48
Formula	C₁₇H₂₇N₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	71675-85-9
PubChem ID	2159
InChi Key	NTJOBXMMWNYJFB-UHFFFAOYSA-N
Smiles	CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amisulpride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	9.24	25 with gentle warming
	DMSO	18.47	50

Preparing Stock Solutions for Amisulpride

The following data is based on the product molecular weight 369.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.41 mL	27.07 mL	54.13 mL
2.5 mM	1.08 mL	5.41 mL	10.83 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

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References for Amisulpride

References are publications that support the biological activity of the product.

Moller Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat.
Perrault Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D₂/D₃ DA receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 1997 PMID: 8996184
Schoemaker Neurochemical characteristics of amisulpride, an atypical DA D₂/D₃ receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 1997 PMID: 8996185

Citations for Amisulpride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Amisulpride include:

Schulz et al. (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol. 167:1480
PMID: 22817643
Midkiff et al. (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One. 6:e25395
PMID: 21966518

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Product Documents for Amisulpride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.