AMG 548

Name: AMG 548
Brand: Tocris Bioscience
SKU: 3920

Tocris Bioscience a Bio-Techne Brand

Catalog # 3920

Citations (1)

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Key Product Details

Description:	Potent and selective p38α inhibitor
Chemical Name:	2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
Purity:	≥98% (HPLC)
Molecular Weight:	461.56

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Biological Activity for AMG 548

AMG 548 is a potent and selective inhibitor of p38α (K_i values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC₅₀ = 3 nM). Efficacious in acute and chronic models of arthritis.

Compound Libraries for AMG 548

AMG 548 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AMG 548

M. Wt	461.56
Formula	C₂₉H₂₇N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	864249-60-5
PubChem ID	11167112
InChi Key	RQVKVJIRFKVPBF-VWLOTQADSA-N
Smiles	O=C1N(C)C(NC[C@@H](N)CC5=CC=CC=C5)=NC(C4=CC=NC=C4)=C1C3=CC2=C(C=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 548

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.8	100
	ethanol	49.8	100

Preparing Stock Solutions for AMG 548

The following data is based on the product molecular weight 461.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.83 mL	21.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for AMG 548

References are publications that support the biological activity of the product.

Dominguez p38 MAP kinase inhibitors: many are made, but few are chosen. Curr.Opin.Drug Discov.Devel. 2005 PMID: 16022178
Lee and Dominguez MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 2005 PMID: 16378500

Citations for AMG 548 (1)

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Citations are publications that use Bio-Techne products. Selected citations for AMG 548 include:

Eckle et al. (2013) HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. J Biol Chem. 11:e1001665
PMID: 24086109

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