AG 99

Name: AG 99
Brand: Tocris Bioscience
SKU: 0497

Tocris Bioscience, part of Bio-Techne | Catalog # 0497

COA / SDS

EGFR-kinase inhibitor

Discontinued Product

0497 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description:	EGFR-kinase inhibitor
Chemical Name:	(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
Purity:	≥99% (HPLC)
Molecular Weight:	204.18

View Full Technical Details for AG 99

Technical Data
Citations

Biological Activity for AG 99

AG 99 is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145^met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.

Technical Data for AG 99

M. Wt	204.18
Formula	C₁₀H₈N₂O₃
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	122520-85-8
PubChem ID	5328768
InChi Key	USOXQZNJFMKTKJ-XVNBXDOJSA-N
Smiles	NC(=O)C(=C\C1=CC(O)=C(O)C=C1)\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for AG 99

References are publications that support the biological activity of the product.

Yamamoto Tyrosine phosphorylation of p145^met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J.Cell Sci. 2006 PMID: 17062641
Gazit Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J.Med.Chem. 1996 PMID: 8960549
Levitzki and Gilon Tyrphostins as molecular tools and potential antiproliferative drugs. TiPS 1991 PMID: 1862529
Gazit Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 1989 PMID: 2552117

AG 99

Tocris Bioscience, part of Bio-Techne | Catalog # 0497

Key Product Details

Biological Activity for AG 99

Technical Data for AG 99

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for AG 99

Product Documents for AG 99

COA

Certificate of Analysis

SDS

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