Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Name: Adenosine 5'-(α,β-methylene)diphosphate sodium salt
Brand: Tocris Bioscience
SKU: 3633
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3633

(1)

Citations (9)

COA / SDS

New Version Available - 8173

Ecto-5'-nucleotidase (CD73) inhibitor

Discontinued Product

3633 has been discontinued. An alternative/replacement product is available: 8173. View all NTPDase Inhibitors products.

Key Product Details

Description:	Ecto-5'-nucleotidase (CD73) inhibitor
Alternative Names:	AMPCP,APCP
Chemical Name:	α,β-Methyleneadenosine 5'-diphosphate monosodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	447.21

View Full Technical Details for Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Technical Data
Citations / Reviews (1)

Biological Activity

Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.

Technical Data

M. Wt	447.21
Formula	C₁₁H₁₆N₅NaO₉P₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	89016-30-8
PubChem ID	91691113
InChi Key	RFGZKSPLJPHQMI-RDJRRFHDSA-M
Smiles	NC1=C2C(N([C@@H]3O[C@H](COP(CP(O)(O[Na])=O)(O)=O)[C@@H](O)[C@@H]3O)C=N2)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References

References are publications that support the biological activity of the product.

Chen Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats. ACS Chem.Neurosci. 2019 PMID: 30913879
Kur Purinergic control of vascular tone in the retina. J.Physiol. 2014 PMID: 24277867
Ujházy Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer. 1996 PMID: 8945621
Niemelä IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 2008 PMID: 18825744

Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 3633

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

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