ACPT-II

Catalog # 1112

Citations (2)

COA / SDS

Discontinued Product

1112 has been discontinued. View all Non-selective mGluR Antagonists products.

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Bio-Techne Corporation

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Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	Competitive mGlu receptor antagonist
Chemical Name:	(1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Molecular Weight:	217.18

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Biological Activity

ACPT-II is a competitive metabotropic receptor antagonist (K_B values are 115, 88 and 77 μM at mGlu_1a, mGlu₂ and mGlu_4a respectively).

Licensing Information

Sold with the permission of the CNRS

Technical Data

M. Wt	217.18
Formula	C₈H₁₁NO₆
Storage	Desiccate at -20°C
CAS Number	195209-04-2
PubChem ID	6604820
InChi Key	FERIKTBTNCSGJS-OBLUMXEWSA-N
Smiles	N[C@]1([C@@](O)=O)C[C@H]([C@](O)=O)[C@H]([C@@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	5
	1.4 eq. NaOH	100

Preparing Stock Solutions

The following data is based on the product molecular weight 217.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.60 mL	23.02 mL	46.04 mL
5 mM	0.92 mL	4.60 mL	9.21 mL
10 mM	0.46 mL	2.30 mL	4.60 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

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References

References are publications that support the biological activity of the product.

Bessis Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12151600
Acher Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 1997 PMID: 9301676

Citations for ACPT-II (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for ACPT-II include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Casado et al. (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci. 97:11593
PMID: 11016958

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