AC 55541

Name: AC 55541
Brand: Tocris Bioscience
SKU: 3369

Tocris Bioscience a Bio-Techne Brand

Catalog # 3369

Citations (6)

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Key Product Details

Description:	Potent and selective PAR₂ agonist
Chemical Name:	(2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide
Purity:	≥97% (HPLC)
Molecular Weight:	518.36

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Biological Activity for AC 55541

AC 55541 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca²⁺ mobilization in vitro (pEC₅₀ values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Technical Data for AC 55541

M. Wt	518.36
Formula	C₂₅H₂₀BrN₅O₃
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	916170-19-9
PubChem ID	9589606
InChi Key	UCUHFWIFSHROPY-RWPZCVJISA-N
Smiles	O=C2C1=CC=CC=C1C(C(NC(C3=CC=CC=C3)=O)C(N/N=C(C)/C4=CC=CC(Br)=C4)=O)=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 55541

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.92	50

Preparing Stock Solutions for AC 55541

The following data is based on the product molecular weight 518.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.86 mL	19.29 mL	38.58 mL
2.5 mM	0.77 mL	3.86 mL	7.72 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

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References for AC 55541

References are publications that support the biological activity of the product.

Seitzberg Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 2008 PMID: 18720984
Gardell Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18768780

Citations for AC 55541 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for AC 55541 include:

Melo et al. (2019) Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression. Cell Death Dis. 10:659
PMID: 31506436
Shi et al. (2019) Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 5
PMID: 31310593
Shi et al. (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. J Immunol. 21:4852
PMID: 25944998
White et al. (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p. Mol Pain. 194:142
PMID: 25429068
Tripathi et al. (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 55:3912
PMID: 24876278
Alkhani et al. (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Neuropsychopharmacology. 10:43
PMID: 24965271

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Showing 1 - 6 of 6 citations Showing All

Product Documents for AC 55541

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.