AC 55541

Name: AC 55541
Brand: Tocris Bioscience
SKU: 3369

Tocris Bioscience, part of Bio-Techne | Catalog # 3369

Citations (13)

COA / SDS

Potent and selective PAR2 agonist

Key Product Details

Description:	Potent and selective PAR₂ agonist
Chemical Name:	(2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide
Purity:	≥97% (HPLC)
Molecular Weight:	518.36

View Full Technical Details for AC 55541

Technical Data
Citations

Biological Activity for AC 55541

AC 55541 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca²⁺ mobilization in vitro (pEC₅₀ values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Technical Data for AC 55541

M. Wt	518.36
Formula	C₂₅H₂₀BrN₅O₃
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	916170-19-9
PubChem ID	9589606
InChi Key	UCUHFWIFSHROPY-RWPZCVJISA-N
Smiles	O=C2C1=CC=CC=C1C(C(NC(C3=CC=CC=C3)=O)C(N/N=C(C)/C4=CC=CC(Br)=C4)=O)=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 55541

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.92	50

Preparing Stock Solutions for AC 55541

The following data is based on the product molecular weight 518.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.86 mL	19.29 mL	38.58 mL
2.5 mM	0.77 mL	3.86 mL	7.72 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

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References for AC 55541

References are publications that support the biological activity of the product.

Gardell Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18768780
Seitzberg Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 2008 PMID: 18720984