AAQ chloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5462
Photoswitchable Kv channel blocker
Discontinued Product
5462 has been discontinued.
View all Voltage-gated Potassium Channel Modulators products.
Key Product Details
Description
Photoswitchable Kv channel blocker
Product Description
AAQ chloride is a photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.Licensing Information
Sold under license from Photoswitch Biosciences, Inc.Product Specifications
Molecular Weight
443.97
Formula
C23H30ClN5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride
PubChem ID
91826090
InChI Key
CTVKLIGDHHKPIB-UHFFFAOYSA-N
SMILES
O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.88 | 20 |
Preparing Stock Solutions
for AAQ chloride
The following data is based on the product molecular weight 443.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.26 mL | 56.31 mL | 112.62 mL |
| 1 mM | 2.25 mL | 11.26 mL | 22.52 mL |
| 2 mM | 1.13 mL | 5.63 mL | 11.26 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Polosukhina Photochemical restoration of visual responses in blind mice. Neuron 2012 PMID: 22841312
- Banghart Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 2009 PMID: 19882609
- Fortin Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 2008 PMID: 18311146
Product Specific Notices for AAQ chloride
For research use only
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