α-Methyl-5-hydroxytryptamine maleate

Name: α -Methyl-5-hydroxytryptamine maleate
Brand: Tocris Bioscience
SKU: 0557

Tocris Bioscience a Bio-Techne Brand

Catalog # 0557

Citations (4)

COA / SDS

Discontinued Product

0557 has been discontinued. View all 5-HT2B Receptor Agonists products.

Key Product Details

Description:	5-HT_2B agonist
Purity:	≥98% (HPLC)
Molecular Weight:	306.32

View Full Technical Details for α-Methyl-5-hydroxytryptamine maleate

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Biological Activity for α-Methyl-5-hydroxytryptamine maleate

5-HT_2B receptor selective agonist with pK_i values of 8.4, 6.1 and 7.3 at 5-HT_2B, 5-HT_2A and 5-HT_2C receptors respectively.

Technical Data for α-Methyl-5-hydroxytryptamine maleate

M. Wt	306.32
Formula	C₁₁H₁₄N₂O.C₄H₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	97469-12-0
PubChem ID	9922558
InChi Key	YQNHFSXRABPJLP-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.CC(N)CC1=CNC2=C1C=C(O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Methyl-5-hydroxytryptamine maleate

Solubility

Soluble Soluble to 10 mM in water and to 100 mM in DMSO

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References for α-Methyl-5-hydroxytryptamine maleate

References are publications that support the biological activity of the product.

Baxter 5-HT₂ receptor subtypes: a family re-united? TiPS 1995 PMID: 7792930
Wilson 5-Hydroxytryptamine₃ receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 1990 PMID: 1968974
Richardson Identification of serotonin M-receptor sub-types and their specific blockade by a new class of drugs. Nature 1985 PMID: 3839291

Citations for α-Methyl-5-hydroxytryptamine maleate (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for α-Methyl-5-hydroxytryptamine maleate include:

Nguyen et al. (2019) Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol. 23:271
PMID: 31297011
Athilingam et al. (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife. 6
PMID: 29206101
Majeed et al. (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast. 2016:7291438
PMID: 26989517
Coulon et al. (2011) Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci. 4:132
PMID: 21267426

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