α-Conotoxin PnIA

Name: α -Conotoxin PnIA
Brand: Tocris Bioscience
SKU: 3123

Tocris Bioscience a Bio-Techne Brand

Catalog # 3123

COA / SDS

Discontinued Product

3123 has been discontinued. View all Additional Nicotinic Receptor Antagonists products.

Key Product Details

Description:	Selective α3β2 nAChR antagonist
Molecular Weight:	1622.82

View Full Technical Details for α-Conotoxin PnIA

Biological Activity for α-Conotoxin PnIA

α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC₅₀ values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data for α-Conotoxin PnIA

M. Wt	1622.82
Formula	C₆₅H₉₅N₁₉O₂₂S₄
Single Letter Sequence	GCCSLPPCAANNPDYC (Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)
Storage	Desiccate at -20°C
CAS Number	705300-84-1
PubChem ID	73755066
InChi Key	VUVGEYBNLLGGBG-MVPSLEAZSA-N
Smiles	[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Conotoxin PnIA

Solubility

Soluble to 5mg/ml in water

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References for α-Conotoxin PnIA

References are publications that support the biological activity of the product.

Everhart Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2003 PMID: 12734390
Luo Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 1999 PMID: 10545176
Fainzilber New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 1994 PMID: 8068627

Citations for α-Conotoxin PnIA

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α-Conotoxin PnIA

Tocris Bioscience a Bio-Techne Brand

Key Product Details

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Biological Activity for α-Conotoxin PnIA

Licensing Information

Technical Data for α-Conotoxin PnIA

Solubility for α-Conotoxin PnIA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for α-Conotoxin PnIA

Citations for α-Conotoxin PnIA

Product Documents for α-Conotoxin PnIA

COA

Certificate of Analysis

SDS

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