8-Chloroadenosine

Name: 8-Chloroadenosine
Brand: Tocris Bioscience
SKU: 4436

Tocris Bioscience, part of Bio-Techne | Catalog # 4436

Citations (3)

COA / SDS

Cytotoxic nucleoside analog; inhibits RNA synthesis

Discontinued Product

4436 has been discontinued. View all DNA, RNA and Protein Synthesis Inhibitors products.

Key Product Details

Description:	Cytotoxic nucleoside analog; inhibits RNA synthesis
Chemical Name:	6-Amino-8-chloropurine riboside
Purity:	≥98% (HPLC)
Molecular Weight:	301.69

View Full Technical Details for 8-Chloroadenosine

Technical Data
Citations

Biological Activity for 8-Chloroadenosine

8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G₂/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Technical Data for 8-Chloroadenosine

M. Wt	301.69
Formula	C₁₀H₁₂ClN₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	34408-14-5
PubChem ID	90488943
InChi Key	MHDPPLULTMGBSI-LZGMGDPASA-N
Smiles	O[C@@H]1[C@@H](CO)OC(N3C2=NC=NC(N)=C2N=C3Cl)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 8-Chloroadenosine

References are publications that support the biological activity of the product.

Gu 8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells Biochem.Pharmacol. 2006 PMID: 16844099
Cervantes-Gomez ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells. J.Pharmacol.Exp.Ther. 2011 PMID: 21821695
Zhang Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 2004 PMID: 15720807

8-Chloroadenosine

Tocris Bioscience, part of Bio-Techne | Catalog # 4436

Key Product Details

Biological Activity for 8-Chloroadenosine

Technical Data for 8-Chloroadenosine

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 8-Chloroadenosine

Product Documents for 8-Chloroadenosine

COA

Certificate of Analysis

SDS

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