673 A
Tocris Bioscience, part of Bio-Techne | Catalog # 6934
ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
Discontinued Product
6934 has been discontinued.
View all Aldehyde Dehydrogenase Inhibitors products.
Key Product Details
Description
ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
Product Description
673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.Product Specifications
Molecular Weight
223.28
Formula
C15H13NO
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde
CAS Number
109437-62-9
PubChem ID
969428
InChI Key
GSAVXYHVHQTGEA-UHFFFAOYSA-N
SMILES
O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.16 | 50 |
Preparing Stock Solutions
for 673 A
The following data is based on the product molecular weight 223.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.96 mL | 44.79 mL | 89.57 mL |
| 2.5 mM | 1.79 mL | 8.96 mL | 17.91 mL |
| 5 mM | 0.90 mL | 4.48 mL | 8.96 mL |
| 25 mM | 0.18 mL | 0.90 mL | 1.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Raghavan Personalized medicine-based approach to model patterns of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids. Clin.Cancer Res. 2017 PMID: 28814433
- Chefetz A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 2019 PMID: 30865894
Product Specific Notices for 673 A
For research use only
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