5'-Fluoroindirubinoxime

Name: 5'-Fluoroindirubinoxime
Brand: Tocris Bioscience
SKU: 4033

Tocris Bioscience, part of Bio-Techne | Catalog # 4033

COA / SDS

FLT3 inhibitor; displays antiproliferative activity

Discontinued Product

4033 has been discontinued. View all Flt-3 Inhibitors products.

Key Product Details

Description:	FLT3 inhibitor; displays antiproliferative activity
Chemical Name:	5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime
Purity:	≥99% (HPLC)
Molecular Weight:	295.27

View Full Technical Details for 5'-Fluoroindirubinoxime

Technical Data
Citations

Biological Activity for 5'-Fluoroindirubinoxime

5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC₅₀ = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Licensing Information

Sold under licence from Anygen Co. Ltd.

Technical Data for 5'-Fluoroindirubinoxime

M. Wt	295.27
Formula	C₁₆H₁₀FN₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	861214-33-7
PubChem ID	11580208
InChi Key	LBUXOYSDWHGJNP-UHFFFAOYSA-N
Smiles	O=C(NC4=C3C=C(F)C=C4)/C3=C2NC1=CC=CC=C1C/2=NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 5'-Fluoroindirubinoxime

References are publications that support the biological activity of the product.

Krivogorsky Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 2008 PMID: 18824607
Choi Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 2010 PMID: 20153646
Kim Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 2007 PMID: 17200363