4F 4PP oxalate

Name: 4F 4PP oxalate
Brand: Tocris Bioscience
SKU: 0523

Catalog # 0523

Citations (3)

COA / SDS

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Key Product Details

Description:	Selective 5-HT_2A antagonist
Chemical Name:	4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate
Purity:	≥99% (HPLC)
Molecular Weight:	429.49

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Biological Activity

4F 4PP oxalate is a selective 5-HT_2A antagonist with almost as high affinity (K_i = 5.3 nM) as Ketanserin (Cat. No. 0908) but with a much lower affinity for 5-HT_2C sites (K_i = 620 nM).

Compound Libraries

4F 4PP oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	429.49
Formula	C₂₂H₂₆FNO.C₂H₂O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	144734-36-1
PubChem ID	24745966
InChi Key	VUJYJCRJPFMHEM-UHFFFAOYSA-N
Smiles	OC(=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCCCC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	20

Preparing Stock Solutions

The following data is based on the product molecular weight 429.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References

References are publications that support the biological activity of the product.

Hagberg Stimulation of 5-HT_2A receptors on astrocytes in primary culture opens voltage-independent Ca²⁺ channels. Neurochem.Int. 1998 PMID: 9542727
Herndon Ketanserin analogues - structure affinity relationships of 5HT₂ and 5HT_1C serotonin receptor binding. J.Med.Chem. 1992 PMID: 1479590

Citations for 4F 4PP oxalate (3)

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Citations are publications that use Bio-Techne products. Selected citations for 4F 4PP oxalate include:

Lee et al. (2018) Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol. 142:1349
PMID: 29920354
Rodríguez-Muñoz et al. (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. 9:23373
PMID: 29805740
Gerhold et al. (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 35:9580
PMID: 26134641

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