4-PPBP maleate

Name: 4-PPBP maleate
Brand: Tocris Bioscience
SKU: 0620

Tocris Bioscience a Bio-Techne Brand

Catalog # 0620

Citations (1)

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Key Product Details

Description:	Specific σ ligand, NMDA antagonist
Chemical Name:	4-Phenyl-1-(4-phenylbutyl)piperidine maleate
Purity:	≥99% (HPLC)
Molecular Weight:	409.52

View Full Technical Details for 4-PPBP maleate

Biological Activity for 4-PPBP maleate

4-PPBP maleate is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes.

Technical Data for 4-PPBP maleate

M. Wt	409.52
Formula	C₂₁H₂₇N.C₄H₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	201216-39-9
PubChem ID	11682970
InChi Key	OASPNIMFGJVLES-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.C(CCC1=CC=CC=C1)CN1CCC(CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-PPBP maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	10.24	25
	DMSO	10.24	25

Preparing Stock Solutions for 4-PPBP maleate

The following data is based on the product molecular weight 409.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.77 mL	48.84 mL	97.68 mL
1.25 mM	1.95 mL	9.77 mL	19.54 mL
2.5 mM	0.98 mL	4.88 mL	9.77 mL
12.5 mM	0.20 mL	0.98 mL	1.95 mL

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References for 4-PPBP maleate

References are publications that support the biological activity of the product.

Whittemore Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 1997 PMID: 9223571
Glennon Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high affinity σ ligands. J.Med.Chem. 1991 PMID: 1662725

Citations for 4-PPBP maleate (1)

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Citations are publications that use Bio-Techne products. Selected citations for 4-PPBP maleate include:

Yang et al. (2007) σ receptor agonists provide neuroprotection in vitro by preserving bcl-2. Front Behav Neurosci. 104:1179
PMID: 17456670

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Product Documents for 4-PPBP maleate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.